Active projects

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  Chlamydiacides: New Antibacterial Compounds

  The project is addressing the issue of antibiotic resistance by creating new antibiotics for threatening and re-emerging infectious diseases due to lack of effective antibiotics or rising prevalence of antibiotic resistance. New compounds have shown effectiveness against Chlamydia at two separate stages of its lifecycle. The proof-of-principle biological data suggests a novel target mode of action that could lead to several broad spectrum antibiotic compounds.
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  Purine metabolism blockers for the treatment of diseases caused by protozoa

  A number of arthropod diseases are caused by protozoan pathogens, such as malaria, leishmaniasis and trypanosomiasis.
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  Changes in Biomarker protein levels in blood

  Assessment and detection of performance enhancement substance abuse in sports and other similar professional occupations are on the rise stemming from the regulatory agencies like the IOC and its counterparts as well as professional sports bodies such as baseball and boxing.
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  Atherosclerosis drug target

  A lipolytic enzyme was shown to facilitate the digestion and absorption of dietary fat in the small intestine. It is also expressed by the lactating mammary gland and secreted with the milk. Milk derived lipolytic enzyme contribute significantly to the efficient utilization of milk fat in newborn human infants. In addition, it is present in low, but significant levels in serum of healthy individuals as well as in the vascular wall.
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  Ameliorating side-effects arising from chemotherapeutic regimen

  Chemotherapy today is a balance of the benefits against the side-effects. While minor side-effects such as hairloss are readily accepted by patients, others are not so benign. A selective reduction of adverse side effects enables the pursuit of more aggressive treatment schedules.
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  Platforms: Diagnostic and High Throughput Screening

  UBI AB has access to numerous experts at the university and in the general market place for incubator project owners to develop new diagnostic kits. The platform provides access to state-of-the-art platform such as the microfluidics slide format for developing "point-of-care" test kits.
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  Hypertriglyceridemia Targets

  High plasma triglyceride (TG) levels are risk factors for several diseases associated with the so called metabolic syndrome. These diseases, mainly associated with our life style (e.g. obesity, diabetes, cardio-vascular disease) are increasing alarmingly both in the western world and in rapidly developing countries.
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  New antibacterial agents targeting secretion systems

  The importance of pathogenic secretion system was recently identified in a number of gram-negative pathogens, e.g., Vibrio cholerae, Pseudomonas aeruginosa, Yersinia pseudotuberculosis, enteroaggregative Escherichia coli and Burkholderia mallei. Many of these are important human pathogens that together cause very extensive morbidity globally.
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  Premature ovarian failure (POF) syndrome

  Premature ovarian failure (POF) syndrome refers ovarian dysfunction before the age of 40, where the ovaries stop producing mature ovum monthly. POF also leads to reduction of estrogen thus presenting symptomologies and health problems associated with menopause.
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  Silica coated nanoparticle –based in vitro diagnostic

  In modern healthcare, in vitro diagnostics (IVD) refer diagnostic tests made on samples from patients, such as blood or urine. The world market for IVD is estimated at 30+ billion USD comprising of many different techniques that require advanced and expensive laboratory equipment as well as highly trained personnel.
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  Ultrathin nanowires production by using amyloid biotemplating

  Nanowires are one of the critical components in the future nanoscale electronic and photonic device applications, such as motor micro-circuitry or if light conducting material are used to form the lighting nanowires.
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  Novel vaccine targets and diagnostic

  Lyme borreliosis (LB) caused by Borrelia spirochetes infection can be subclinical (asymptomatic) and occasionally become chronic and persists for several years. Clinical presentations can generally be divided into three stages—early localized LB, early disseminated LB and late (chronic) LB—but may not progress from an early to later stage, even if the infection is untreated.
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  Oncolytics: Therapeutic Modality for solid tumours

  The global burden of people living with cancer is about 30 million, 7 million deaths and 12 million new cancer cases for the period 2007, which was calculated according to cancer diagnosis and deaths from 26 different cancer types (Global Cancer Treatment Forecast to 2012 from RNCOS). Thus, there is a demand for novel therapeutic modes to address this medical need.
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